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Briefly, leukemia cells were seeded in 384-well, black, optically clear flat-bottom PhenoPlate (PerkinElmer, Waltham, MA) with collagen I (PureCol, Advanced Biomatrix, Carlsbad, CA) to a total volume of 9 l, containing approximately 3,000 leukemia cells in each well

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ELISA assay for DNA fragmentation DNA fragmentation was quantified using a commercially available ELISA kit from Roche (Indianapolis, IN) in accordance with the manufacturers instructions